Ultra Homemade Drain Cleaner A stronger version of homemade drain cleaner than JUST using vinegar and baking soda. This more intense formula should loosen even tougher clogs in the drain. NATURAL DRAIN CLEANER - Make It Yourself 1 cup baking soda 1 cup table salt 1/4 cup cream of tartar 1 cup boiling water Cold Water. Mix baking soda, table salt, and cream of tartar. Stir each time before using. Keep in a clean, covered jar. When ready to use, pour 1/4 cup of mixture into drain. Immediately add the 1 cup boiling water. Wait ten seconds, then flush with cold water for at least 20 seconds.